Video Game Forums

Frederick and Eleanor Little are a happily married couple living in New York City, intending to adopt a younger brother for their son, George. When they visit the orphanage, they meet a young anthropomorphic mouse named Stuart and, despite the head of the orphanage Mrs. Keeper's initial objections, choose him instead. Upon returning home, Stuart struggles to fit in; George is disappointed and refuses to acknowledge Stuart as his brother, and the family cat, Snowbell, is disgusted at the fact that he is now a pet to a mouse. Eleanor then goes on to accidentally trap Stuart in the washing machine one morning after a load of laundry. She rescues Stuart from swallowing too much detergent, but Stuart becomes ill as he coughs up soap bubbles. Stuart then recovers after a visit from Dr. Beechwood.

After Stuart admits to the Littles that he feels an empty space inside him, they meet with Mrs. Keeper to find out some information about Stuart's real parents, but are told nothing due to confidentiality. As time goes by, George and Stuart start to bond after Stuart encourages him to finish making his model boat for an upcoming race. Meanwhile, Snowbell and his friend Monty host a meeting with a rogue alley cat named Smokey and hatch a plan to have Stuart removed from the household.

On the day of the race, Stuart accidentally breaks George's remote control, rendering his boat inoperable. He jumps in and takes control of it himself, narrowly avoiding a crash on the water and subsequently winning the race. Later that night while celebrating, they are interrupted by a mouse couple who arrive at the house; they introduce themselves as Reggie and Camille Stout, and claim to be Stuart's biological parents who were forced to give him up due to poverty. The Littles reluctantly agree to allow Stuart to leave with the Stouts, leaving George forlorn.

The orphanage contacts the Littles to ask how Stuart is doing, and when Frederick and Eleanor explain he has gone home with his real parents, Mrs. Keeper informs them that Stuart's real parents died several years earlier when a canned food pyramid fell on them in a supermarket, hence why he was put up for adoption to begin with. Realizing Stuart has been kidnapped (a ploy organized by Snowbell and the other cats), the family organize a huge search party around the city. Fearing that his involvement in the deception will be exposed, Snowbell informs Smokey that the Littles have found out about the Stouts, so Smokey decides Stuart must be killed instead.